Production and characterization of endocrine cells derived from human pancreas organoids for cell-based therapy of
type 1 diabetes
LSFM4LIFE is a project.
The aim of LSFM4LIFE is the isolation and therapeutic-scale manufacture of human pancreas organoids for the cellular therapy of type 1 diabetes (T1D). Pancreas organoids, which are grown from adult stem cells, are a small in vitro version of pancreas. The production of pancreas organoids from adult stem cells has been established in 2013.
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10/10/2019EOS2019 – a good reason to go to Milan
09/10/2019LSFM4LIFE at EOS2019
18/09/2019Objectives
LSFM4LIFE develops tools and technologies for the advanced cell therapy of type 1 diabetes
Production
LSFM4LIFE produces long-term renewing, human pancreatic organoids (hPO) for T1D therapy and characterizes their genetic stability and in vivo safety.
Screening
LSFM4LIFE identifies the optimal expansion and differentiation conditions of hPO by employing high-throughput screening.
Standardization
LSFM4LIFE standardizes the manufacture of hPO under xenogen-free and well-defined biochemical conditions, by employing new biomimetic scaffolds.
Compliance
LSFM4LIFE achieves regulatory-compliant GMP production of hPO for pre-clinical studies and phase I clinical trials.
