Production and characterization of endocrine cells derived from human pancreas organoids for cell-based therapy of
type 1 diabetes
LSFM4LIFE is a project.
The aim of LSFM4LIFE is the isolation and therapeutic-scale manufacture of human pancreas organoids for the cellular therapy of type 1 diabetes (T1D). Pancreas organoids, which are grown from adult stem cells, are a small in vitro version of pancreas. The production of pancreas organoids from adult stem cells has been established in 2013.
LSFM4LIFE on Rai30/04/2019
EU project LSFM4LIFE. A new video to raise awareness about Type 1 Diabetes (T1D)25/04/2018
January 2018 – A new video to raise awareness about Type 1 Diabetes19/03/2018
LSFM4LIFE develops tools and technologies for the advanced cell therapy of type 1 diabetes
LSFM4LIFE produces long-term renewing, human pancreatic organoids (hPO) for T1D therapy and characterizes their genetic stability and in vivo safety.
LSFM4LIFE identifies the optimal expansion and differentiation conditions of hPO by employing high-throughput screening.
LSFM4LIFE standardizes the manufacture of hPO under xenogen-free and well-defined biochemical conditions, by employing new biomimetic scaffolds.
LSFM4LIFE achieves regulatory-compliant GMP production of hPO for pre-clinical studies and phase I clinical trials.